Ed nails it on the head! When it comes to questions about speakers, be ready to open the can of worms!
When you're talking a pair of Mackies vs. a home theater surround system we're really talking about 2 very different set-ups and it's hard to make an even comparison between 2 speakers alone no matter how good they are up against strategically placed multiple speakers. Then there's the question of what kind of sample sets you're using (wet or dry) and what's the best approach for either to get the best results. Although the 2 Mackies (or another pair of X brand monitors) will likely sound very good, there's really no comparing them by themselves to the dramatic difference in the sound field you will achieve with multiple speakers in a surround set-up, it's like going from 2 dimensional to 3.
There's no substitution for either multiple amps and speakers, a multi-channel amp and speakers or multi powered monitors as you see illustrated here quite often, but if you're looking for a decent sounding minimal fuss set-up
providing your plans are for wet sets (dry sets are a whole different deal), either unhook and drag your Onkyo system over to the organ room and give it a try first to see how you like it, or go out and pick up another surround system that is comparable or maybe even up the ladder a ways as it sounds like your budget permits, save yourself all the relocating work, set up the new system with the front and rear speaker arrangement as it is intended, use your on-board Mac sound card (which I understand are pretty good as is), you will end up with a very respectable sounding system, and enjoy!
If you haven't done so already, read this post as you might pick up a few ideas here as well >>
viewtopic.php?f=17&t=13910 Marc