Here's an update to my experience with the Scarlett 18i20 interface running with Windows 10. This has been a great interface with the following caveat. The 18i20 requires a USB 2.0 port. Connections to three versions of USB 3.0 ports have worked initially but have been subject to disconnects, sometimes after several hours and sometimes when changing clock rates or turning Reaper off and back on.
The Focusrite manual specifies a USB 2.0 port, but their service rep has stated that the interface is fine with Windows 10 and USB 3.0 I have a support case open with them and will update this post if anything changes. Using USB 2.0 has been rock solid for several weeks now so there is a simple enough work-around. When the USB ports fail I haven't found a solution short of rebooting the PC. I'm going to try the interface with my Mac mini USB 3.0 ports when I find time.
The three USB 3.0 versions that gave problems were:
Intel C610, part of X99 chipset, driver 10.1.2.9, 7/28/2015
VIA USB 3.0 eXtensible Host Controller, driver 10.0.10586.0, 10/29/2015
ASMedia ASM1142 3.1 controller — don’t have driver details
EDIT: I received excellent assistance from Focusrite support in spite of the fact that their interface was 100% functional when I used a USB 2.0 port. They pointed me to an Intel Automatic Updater that provided a newer file than what MSI had on their site. Same with VIA though their web site was a bit cryptic in terms of locating the best driver. Interestingly, Microsoft sent an upgrade today with a new ASMedia driver which didn't work for me, but it apparently cleaned something in the registry as I was then able to load an even newer driver from the MSI site. Interesting experience as I was apparently too trusting of the motherboard manufacturer's "latest" drivers.
So I can now recommend the Focusrite Scarlett 18i20 with no reservations of any kind.
The Focusrite manual specifies a USB 2.0 port, but their service rep has stated that the interface is fine with Windows 10 and USB 3.0 I have a support case open with them and will update this post if anything changes. Using USB 2.0 has been rock solid for several weeks now so there is a simple enough work-around. When the USB ports fail I haven't found a solution short of rebooting the PC. I'm going to try the interface with my Mac mini USB 3.0 ports when I find time.
The three USB 3.0 versions that gave problems were:
Intel C610, part of X99 chipset, driver 10.1.2.9, 7/28/2015
VIA USB 3.0 eXtensible Host Controller, driver 10.0.10586.0, 10/29/2015
ASMedia ASM1142 3.1 controller — don’t have driver details
EDIT: I received excellent assistance from Focusrite support in spite of the fact that their interface was 100% functional when I used a USB 2.0 port. They pointed me to an Intel Automatic Updater that provided a newer file than what MSI had on their site. Same with VIA though their web site was a bit cryptic in terms of locating the best driver. Interestingly, Microsoft sent an upgrade today with a new ASMedia driver which didn't work for me, but it apparently cleaned something in the registry as I was then able to load an even newer driver from the MSI site. Interesting experience as I was apparently too trusting of the motherboard manufacturer's "latest" drivers.
So I can now recommend the Focusrite Scarlett 18i20 with no reservations of any kind.