I don't know, I'm afraid, but my M-Audio FireWire Audiophile with M-Audio's latest/final driver for it (FireWire Installer 6.0.1 Driver 5.10.0.5058, officially intended for 64-bit Window 7 SP1) still works properly in Hauptwerk (with the M-Audio ASIO driver selected) on Windows 10 today, with all of the latest Windows 10 updates.
My FireWire Audiophile uses the same driver that a FireWire 410 uses (or both are installed by the same driver installer, at least), and both models are discontinued and only officially supported by M-Audio up to Windows 7 SP1, but mine still works anyway.
Perhaps try checking for any further Windows updates that might be available since the ones you last applied, and also try (re-)installing that latest/final 6.0.1 driver ( http://www.m-audio.com/support/drivers-search ) then rebooting the PC.
jrball wrote:Bad: HW starts but shows load error: "DirectSound Device 'DirectSound 7/8 (M-Audio FW 410) could not be opened..."
I'd highly recommend using M-Audio's ASIO driver in Hauptwerk, rather than DirectSound. (ASIO should give much better performance and lower latencies.) Also make sure that no other software is running at the same time as Hauptwerk that might try to play audio through the same audio interface. Since you also have the M-Audio selected as Windows' default playback device, you would probably need to make sure that all Windows sounds are disabled, to try to prevent Windows playing sounds through it whilst Hauptwerk is using it.