Hello atugores,
We tested Hauptwerk v4.2.1 with the current macOS 10.13 High Sierra beta version and we'll post an official statement once the final version of High Sierra is released publicly by Apple in the coming week.
(Broadly, yes -- it did work as well as mac OS 10.12.2+, but since it's only available in beta version we need to await the final release from Apple before we can make a definitive statement.)