Greeting Adri,
I think you are still using Hauptwerk 4 and re-installed Windows 10 in January (searching your previous posts). Guessing that since that time all was fine.
Do you know if Windows 10 updated lately? Have you try to re-installed your audio interface drivers?
When the audio crashes/stops, if you go to to Engine | Advanced use | Stop audio engine then go back Start audio engine ... do you get any error message. Any error messge when exiting Hauptwerk?
Do you have this problem with all your sample sets or only a specific one? If a specific one, are you crashing when playing a specific note and stop?
Does the audio stops while playing or does it stops after leaving the console for a while and returning to it to play some more? (In that case check your energy saving parameters and make sure that USB doesn't power down.) You can also try to connect your audio interface to another USB connector.
Have you checked how much free memory you have? Ideally try to have at least from 1.5 to 2Gb free