Hello Lukas,
[Topic moved here.]
If you're using Hauptwerk v6 and have the 'high-definition pitch-shifting' audio engine preference ticked for the organ then Hauptwerk uses extremely high-quality pitch-shifting and there wouldn't any audible loss of audio quality (distortion) even with large pitch shifts (e.g. more than an octave). Hence provided that you have that preference ticked you don't need to worry about it.
Without that preference ticked (or in v5 or earlier, which didn't have that ability), larger pitch shifts would give some audible distortion. However the difference between 440 and 446 Hz is fairly small, so the distortion would be small anyway.
If your CPU is powerful enough, I'd always recommend keeping the 'high-definition pitch-shifting' preference ticked.