Hello Rod,
All organs' caches will need to be regenerated within any configuration whose settings you restore from backup (since the settings you restored might have different rank memory options from those prior to restoring the backup).
When restoring a backup there is an option for 'advanced' or 'basic' restore mode. Basic mode restores all settings for all configurations (and therefore will cause all configurations' organs' caches to regenerate), whereas in 'advanced' mode you can choose to restore just a single configuration. In the latter case other configurations' caches wouldn't need to regenerate.