
I would check that the HW Midi out settings for the 2i4 are the same as your other (working) interface - both should be set as devices for the console output midi stream. HW will warn that one of them is offline when it starts and offer you the option to keep the device configured but mark it temporarily off line; you need to select the option to keep the device configured, but marked offline.
I think there is nothing to set in the 2i4.
Iain